异常信号传导与肿瘤形成有关，包括磷酸肌醇 3-激酶 (PI3K)/Akt、哺乳动物雷帕霉素靶蛋白 (mTOR)、Wnt/β-连环蛋白、丝裂原活化蛋白激酶 (MAPK)、信号转导和转录激活因子3（STAT3）和缺口信号通路。靶向化疗已被证明可成功治疗某些恶性肿瘤。然而，其功效常常受到耐药性和对正常组织和细胞的副作用的限制。免疫疗法是一个备受关注的有前景的领域。除了异常的肿瘤信号通路，靶向癌症干细胞和 microRNA 在癌症药物开发中发挥着关键作用。众所周知，肿瘤干细胞是导致耐药和肿瘤复发的主要原因。微小RNA调节促进肿瘤发生的多个关键信号通路。
本期特刊旨在整理描述这些有希望的抗癌靶点的原始研究和评论文章，包括 (PI3K)/Akt、mTOR、Wnt/β-Catenin、MAPK、STAT3 和 notch 信号通路以及癌症干细胞、microRNA ，以及其他关键目标。此外，在临床试验的各个阶段描述有前景的天然和合成来源的候选药物的文章也受到欢迎。
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