Virology Journal is an Open Access, peer-reviewed, online journal that presents high-quality original research concerning viruses, and establishes a strategic alternative to the traditional virology communication process. Virology Journal will feature articles on human, animal, plant, insect, bacterial, and fungal viruses. The journal will also publish articles on molecular aspects of the control and prevention of viral infections with vaccines and antiviral agents and on the use of viruses as gene therapy vectors. The approaches and techniques used are expected to encompass many disciplines, including molecular genetics, molecular biology, biochemistry, biophysics, structural biology, cell biology, immunology, morphology, genetics and pathogenesis. The outbreaks of SARS coronavirus, West Nile virus, and monkeypox virus are but a few recent examples of the urgent need for a rapid forum for communications among virologists. Virology Journal will meet the rapid communication needs in virology.