Chemical Reviews provides comprehensive and expert critical analysis in organic, inorganic, physical, analytical, theoretical, and biological chemistry. Periodic thematic issues focusing on a single theme or direction of emerging research have been published since 1985 and are available for purchase individually. "Bioinorganic Enzymology," published in 1996, is one such thematic issue and has sold more than 1,000 copies to date.

Chemical Reviews is one of the most highly regarded and highest-ranked journals covering the general topic of chemistry.

The mission of Chemical Reviews is to provide comprehensive, authoritative, critical, and readable reviews of important recent research in organic, inorganic, physical, analytical, theoretical, and biological chemistry.

In addition to the general reviews, the journal has published since 1985 periodic thematic issues focusing on a single theme or direction of emerging research.