Retrovirology is an Open Access, online journal that publishes stringently peer-reviewed, high-impact articles on basic retrovirus research. Retroviruses are pleiotropically found in animals. Well-described examples include avian, murine and primate retroviruses. Two human retroviruses are especially important pathogens. These are the human immunodeficiency virus, HIV, and the human T-cell leukemia virus, HTLV. HIV causes AIDS while HTLV-I is the etiological agent for adult T-cell leukemia. There is a large amount of basic research being conducted on HIV and HTLV-I spanning gene expression, virus structure-assembly, integration, replication, and pathogenesis. Retrovirology intends to cover these areas of human and animal retrovirus research. In any given issue of an extant print virology journal, research papers on retroviruses, especially primate retroviruses, make up the largest subcategory of manuscripts. Retroviruses are responsible for many kinds of medically important pathologies including immunodeficiencies and cancers. Hence, there is a large publication demand and a significant research interest for an Open Access journal, which emphasizes basic retrovirus research. The Open Access format is ideally suited for communicating cutting edge information to a large audience quickly.